We initiated this research project to improve the dissemination of trustworthy clinical practice guidelines by outlining a structured adaptation process for guidelines developed with the GRADE system. Results from these dissemination and adaptation strategies have successfully been implemented in MAGICapp in real life clinical practice guidelines.

Collaborating with the DECIDE project we developed user-friendly multilayered presentation formats readable on any electronic device. Recommendations are displayed first with the underlying content available by clicking on the recommendation.

Our new presentation format tested favourably against currently available formats in a randomized trial. Building on current evidence and existing tools for adaptation of guidelines (e.g. ADAPTE) we further developed and evaluated a new 5-step adaptation framework customised to guidelines developed with the GRADE system. 

We specifically aimed to increase efficiency while maintaining transparency and trustworthiness throughout the adaptation process. We performed a real-life application of the framework through the development of a Norwegian guideline for antithrombotic therapy, also implementing the multilayered presentation format.